| http://purl.uniprot.org/citations/26267534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26267534 | http://www.w3.org/2000/01/rdf-schema#comment | "Nearly 50% of human malignancies exhibit unregulated RAS-ERK signaling; inhibiting it is a valid strategy for antineoplastic intervention. Upon activation, ERK dimerize, which is essential for ERK extranuclear, but not for nuclear, signaling. Here, we describe a small molecule inhibitor for ERK dimerization that, without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. This compound is unaffected by resistance mechanisms that hamper classical RAS-ERK pathway inhibitors. Thus, ERK dimerization inhibitors provide the proof of principle for two understudied concepts in cancer therapy: (1) the blockade of sub-localization-specific sub-signals, rather than total signals, as a means of impeding oncogenic RAS-ERK signaling and (2) targeting regulatory protein-protein interactions, rather than catalytic activities, as an approach for producing effective antitumor agents."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2015.07.001"xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Jones M."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Keri G."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Pineda-Lucena A."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Rivas G."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Vidal R."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Herrero A."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Pinto A."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Horvath Z."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Nuciforo P."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Pazos A."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Orfi L."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Crespo P."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Tenbaum S.P."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Palmer H.G."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Hurlstone A."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Casar B."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Agudo-Ibanez L."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Valdizan E.M."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Colon-Bolea P."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Bony E."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/author | "Gozalbes R."xsd:string |
| http://purl.uniprot.org/citations/26267534 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |