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http://purl.uniprot.org/citations/26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26273660http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients.

Methods

We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course.

Results

Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of <1.2447 and >4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and <2.2, respectively, were 80% sensitive and 100% specific for the absence of infection in febrile SLE patients.

Conclusion

The C4d/CR1 ratio is a simple and quickly determinable biomarker that enables the differentiation between infection and flare-up in febrile SLE patients at initial evaluation. Further, when combined with the CRP level, it is useful to evaluate disease activity in SLE patients with infection."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.org/dc/terms/identifier"doi:10.1155/2015/939783"xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/author"Chen C.H."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/author"Chen H.C."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/author"Lin Y.F."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/author"Yang D.H."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/author"Peng M.Y."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/author"Tai S.B."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/name"Biomed Res Int"xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/pages"939783"xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/title"Analysis of Erythrocyte C4d to Complement Receptor 1 Ratio: Use in Distinguishing between Infection and Flare-Up in Febrile Patients with Systemic Lupus Erythematosus."xsd:string
http://purl.uniprot.org/citations/26273660http://purl.uniprot.org/core/volume"2015"xsd:string
http://purl.uniprot.org/citations/26273660http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26273660
http://purl.uniprot.org/citations/26273660http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26273660
http://purl.uniprot.org/uniprot/#_E9PDY4-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_A0A346RCT4-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_A0A346RD54-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_A0A346RD63-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_A0A346RD80-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_A0A346RD82-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_A0A2S1GUW1-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_A0A2S1GUW8-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
http://purl.uniprot.org/uniprot/#_B4DPT3-mappedCitation-26273660http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26273660
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