| http://purl.uniprot.org/citations/26280121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26280121 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-α (TNF-α), one of the major stress-induced proinflammatory cytokines, is upregulated in the heart after tissue injury, and its sustained expression can contribute to the development of heart failure. Whether TNF-α also exerts cytoprotective effects in heart failure is not known. Here we provide evidence for a cardioprotective function of TNF-α in a genetic heart failure model, desmin-deficient mice. The cardioprotective effects of TNF-α are a consequence of nuclear factor-κB (NF-κB)-mediated ectopic expression in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-specific intermediate filament proteins. In cardiomyocytes, K8 and K18 (K8/K18) formed an alternative cytoskeletal network that localized mainly at intercalated discs (IDs) and conferred cardioprotection by maintaining normal ID structure and mitochondrial integrity and function. Ectopic induction of K8/K18 expression in cardiomyocytes also occurred in other genetic and experimental models of heart failure. Loss of the K8/K18 network resulted in a maladaptive cardiac phenotype following transverse aortic constriction. In human failing myocardium, where TNF-α expression is upregulated, K8/K18 were also ectopically expressed and localized primarily at IDs, which did not contain detectable amounts of desmin. Thus, TNF-α- and NF-κB-mediated formation of an alternative, stress-induced intermediate filament cytoskeleton has cardioprotective function in mice and potentially in humans."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3925"xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Maier H.J."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Soriano M.E."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Capetanaki Y."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Mann D.L."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Kaklamanis L."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Varela A."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Rickelt S."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Davos C.H."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Schips T.G."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/author | "Papathanasiou S."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/pages | "1076-1084"xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/title | "Tumor necrosis factor-alpha confers cardioprotection through ectopic expression of keratins K8 and K18."xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/26280121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26280121 |
| http://purl.uniprot.org/citations/26280121 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26280121 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-26280121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26280121 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-26280121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26280121 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-26280121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26280121 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-26280121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26280121 |
| http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-26280121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26280121 |