| http://purl.uniprot.org/citations/26282200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26282200 | http://www.w3.org/2000/01/rdf-schema#comment | "Free fatty acids (FFAs) act as extracellular signaling molecules through binding to G-protein-coupled FFA receptors (FFARs). GPR120 and GPR40 are identified as FFARs for medium- and long-chain fatty acids. In the present study, we investigated roles of GPR120 and GPR40 in cellular functions of pancreatic cancer PANC-1 cells, using GPR120 and GPR40 knockdown cells (PANC-sh120 and PANC-sh40 cells respectively). In cell motility assay, PANC-sh120 cells showed the low cell motility, compared with control cells. In contrast, the cell motility of PANC-sh40 cells was significantly higher than that of control cells. Activity levels of matrix metalloproteinases (MMPs) were measured by gelatin zymography. While PANC-sh120 cells indicated the reduced MMP-2 activity, MMP-2 activity in PANC-sh40 cells was significantly higher than that in control cells. On the other hand, no activation of MMP-9 was detected in all cells. In colony assay, the large sized colonies were markedly formed in PANC-sh40 cells. No colony formation was observed in PANC-sh120 cells as well as control cells. These results suggest that distinct effects of GPR120 and GPR40 are involved in the acquisition of malignant property in pancreatic cancer cells."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.08.050"xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Fukushima K."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Ishii S."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Honoki K."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Tsujiuchi T."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Fukushima N."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Yamasaki E."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Hirane M."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/author | "Tomimatsu A."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/pages | "512-515"xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/title | "Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells."xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://purl.uniprot.org/core/volume | "465"xsd:string |
| http://purl.uniprot.org/citations/26282200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26282200 |
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