| http://purl.uniprot.org/citations/26286991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26286991 | http://www.w3.org/2000/01/rdf-schema#comment | "The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs following tissue damage remain unclear. Using a virus-induced model of autoantibody formation in the salivary glands of adult mice, we demonstrate that IL-22 provides a mechanistic link between mucosal infection, B-cell recruitment, and humoral autoimmunity. IL-22 receptor engagement is necessary and sufficient to promote differential expression of chemokine (C-X-C motif) ligand 12 and chemokine (C-X-C motif) ligand 13 in epithelial and fibroblastic stromal cells that, in turn, is pivotal for B-cell recruitment and organization of the TLOs. Accordingly, genetic and therapeutic blockade of IL-22 impairs and reverses TLO formation and autoantibody production. Our work highlights a critical role for IL-22 in TLO-induced pathology and provides a rationale for the use of IL-22-blocking agents in B-cell-mediated autoimmune conditions."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1503315112"xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Bowman S."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Fisher B."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Campos J."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Buckley C.D."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Luther S.A."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Randall T.D."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Pitzalis C."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Barone F."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Fouser L."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Toellner K.M."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Nayar S."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Lucchesi D."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Rangel-Moreno J."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Bombardieri M."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Withers D.R."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Garcia-Hernandez M.d.e. L."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/author | "Cloake T."xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/pages | "11024-11029"xsd:string |
| http://purl.uniprot.org/citations/26286991 | http://purl.uniprot.org/core/title | "IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs."xsd:string |