| http://purl.uniprot.org/citations/26288354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26288354 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymic stromal lymphopoietin (TSLP) is overtly expressed on skin lesions of atopic dermatitis (AD), and the initiative role of TSLP-activated DCs in AD has gained much attention in the past few years, while its actions on other immune cells such as T cells have been given less notice. We aimed to clarify whether TSLP receptor (TSLPR) is expressed on certain populations of T cells and whether TSLP possesses the capability to directly interact with T cells from AD patients. Peripheral lymphocytes from 51 AD patients are analyzed by flow cytometry, and ex vivo experiments using peripheral blood and lesional skin-derived T cells were conducted. TSLPR expression was defined to CD4+ T cells, and CD4+CCR4+CXCR3-CCR7-CCR10+CLA+ T cells in AD patients exhibited enhanced TSLPR expression. The frequency of TSLPR+CD4+ T cells correlated with disease activity. CD4+ T cells from AD patients directly interacted with TSLP to produce a higher amount of IL-4 than those from normal subjects, and this action was attenuated with anti-TSLPR antibody. The importance of IL-4 in the induction of TSLPR expression was found in AD T cells. Our findings indicate that T cells from AD patients possess strong potential to directly interact with TSLP to promote Th2 response."xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2015.318"xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/author | "Waki M."xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/author | "Tatsuno K."xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/author | "Tokura Y."xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/author | "Fujiyama T."xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/pages | "3017-3024"xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/title | "TSLP Directly Interacts with Skin-Homing Th2 Cells Highly Expressing its Receptor to Enhance IL-4 Production in Atopic Dermatitis."xsd:string |
| http://purl.uniprot.org/citations/26288354 | http://purl.uniprot.org/core/volume | "135"xsd:string |
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