| http://purl.uniprot.org/citations/26289945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26289945 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the current study was to determine genotype effects of four single nucleotide polymorphisms (SNPs) in the genes of the N-Methyl-d-aspartate receptor (GRIN1, GRIN2A, GRIN2C) and kainate receptor (GRIK1), which have been previously associated with alcoholism, on behavior, neural cue-reactivity and drinking outcome. Eighty-six abstinent alcohol dependent patients were recruited from an in-patient setting. Neuropsychological tests, genotyping and functional magnetic resonance imaging (fMRI) were used to study genotype effects. GRIN2C risk allele carriers displayed increased alcohol cue-induced activation in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (dlPFC). Neural activation in the ACC positively correlated with craving for alcohol (r = 0.201, P = 0.032), whereas activation in the dlPFC showed a negative association (r = -0.215, P = 0.023). In addition, dlPFC activation predicted time to first relapse (HR = 2.701, 95%CI 1.244-5.864, P = 0.012). GRIK1 risk allele carriers showed increased cue-induced activation in the medial prefrontal (PFC) and orbitofrontal cortex (OFC) and in the lateral PFC and OFC. Activation in both clusters positively correlated with alcohol craving (rmedOFC, medPFC = 0.403, P = 0.001, rlatOFC, latPFC = 0.282, P = 0.008), and activation in the cluster that encompassed the medial OFC predicted time to first relapse (HR = 1.911, 95%CI 1.030-3.545, P = 0.040). Findings indicate that SNPs in the GRIN2C and GRIK1 genes are associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.org/dc/terms/identifier | "doi:10.1111/adb.12291"xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Beck A."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Frank J."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Mann K."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Rietschel M."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Kiefer F."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Hoffmann S."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Heinz A."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Bach P."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Kirsch M."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Walter H."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Vollstadt-Klein S."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Charlet K."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/author | "Jorde A."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/name | "Addict Biol"xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/pages | "1022-1032"xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/title | "The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving."xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/26289945 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26289945 |
| http://purl.uniprot.org/citations/26289945 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26289945 |
| http://purl.uniprot.org/uniprot/#_E9PD61-mappedCitation-26289945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26289945 |
| http://purl.uniprot.org/uniprot/#_A0A8D9PH76-mappedCitation-26289945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26289945 |