| http://purl.uniprot.org/citations/26299309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26299309 | http://www.w3.org/2000/01/rdf-schema#comment | "Skeletal muscle is composed of both slow-twitch oxidative myofibers and fast-twitch glycolytic myofibers that differentially impact muscle metabolism, function and eventually whole-body physiology. Here we show that the mesodermal transcription factor T-box 15 (Tbx15) is highly and specifically expressed in glycolytic myofibers. Ablation of Tbx15 in vivo leads to a decrease in muscle size due to a decrease in the number of glycolytic fibres, associated with a small increase in the number of oxidative fibres. This shift in fibre composition results in muscles with slower myofiber contraction and relaxation, and also decreases whole-body oxygen consumption, reduces spontaneous activity, increases adiposity and glucose intolerance. Mechanistically, ablation of Tbx15 leads to activation of AMPK signalling and a decrease in Igf2 expression. Thus, Tbx15 is one of a limited number of transcription factors to be identified with a critical role in regulating glycolytic fibre identity and muscle metabolism."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9054"xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Kahn C.R."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Ussar S."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Goodyear L.J."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Hirshman M.F."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Kispert A."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Singh M.K."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/author | "Wetzel P."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/pages | "8054"xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/title | "Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism."xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26299309 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26299309 |
| http://purl.uniprot.org/citations/26299309 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26299309 |
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