| http://purl.uniprot.org/citations/26300492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26300492 | http://www.w3.org/2000/01/rdf-schema#comment | "Characterization of the exome and genome of carcinoma (ccRCC) by next-generation sequencing identified numerous genetic alternations. BRCA1-associated protein-1 (BAP1) was identified as one of the most frequently mutated genes in ccRCC, suggesting that BAP1 is a potential key driver for ccRCC cancer initiation and progression. However, how BAP1 mutations contribute to ccRCC remains to be elucidated. BAP1 is a nuclear de-ubiquitinating enzyme and cleaves the ubiquitin chain from the substrates. Here, we identified MCRS1 as a bona fide substrate for BAP1. MCRS1 is a component of the centrosome proteins, and plays an essential role in spindle assembly. BAP1 binds to MCRS1 and stabilizes MCRS1 by de-ubiquitination. BAP1 contributes to chromosome stability partially via MCRS1. A positive correlation was identified between BAP1 and MCRS1 expression in ccRCC tissues. Both BAP1 loss and MCRS1 down-regulation in ccRCC were associated with adverse clinicopathological features. This study revealed a novel mechanism for BAP1 involved in MCRS1 stability regulation, and provided insight in understanding the relationship between BAP1 mutations and chromosome instability in ccRCC."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2015.08.013"xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Gao K."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Xiao J."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Jin X."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/author | "Mo R."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/pages | "167-174"xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/title | "Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://purl.uniprot.org/core/volume | "369"xsd:string |
| http://purl.uniprot.org/citations/26300492 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26300492 |
| http://purl.uniprot.org/citations/26300492 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26300492 |
| http://purl.uniprot.org/uniprot/#_A0A346RV25-mappedCitation-26300492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26300492 |
| http://purl.uniprot.org/uniprot/#_A0A4V1DYV2-mappedCitation-26300492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26300492 |
| http://purl.uniprot.org/uniprot/#_B3KS40-mappedCitation-26300492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26300492 |
| http://purl.uniprot.org/uniprot/#_B4DI37-mappedCitation-26300492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26300492 |
| http://purl.uniprot.org/uniprot/#_Q92560-mappedCitation-26300492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26300492 |