| http://purl.uniprot.org/citations/26303065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26303065 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain-derived neurotrophic factor (BDNF) has been implicated in the potent modulation of synaptic plasticity at both pre-synaptic and post-synaptic sites. However, the molecular mechanism underlying BDNF-mediated pre-synaptic modulation remains incompletely understood. Here, we report that BDNF treatment for over 4 h could significantly enhance the expression of c-Jun NH2-terminal kinase-interacting protein 3 (JIP3) in cultured hippocampal neurons. This enhancement could be blocked by the Trk inhibitor K252a or by a cAMP response element-binding protein (CREB) inhibitor. In addition, chromatin immunoprecipitation (ChIP) assays revealed that CREB could bind with the JIP3 promoter region and the BDNF treatment could increase this binding. Using dual-luciferase assays we further characterized the cAMP response element (CRE) site in the JIP3 promoter. Finally, we found that BDNF-increased JIP3 expression contributes to the BDNF-induced modulation of neurotransmitter release. Together, our studies reveal that in hippocampal neurons BDNF up-regulates JIP3 expression via CREB activation, which contributes to the enhancement of neurotransmitter release; thus, we have identified a novel mechanism that BDNF modulates pre-synaptic transmission."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.org/dc/terms/identifier | "doi:10.1111/jnc.13226"xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/author | "Chen Z.Y."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/author | "Guo Y.Y."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/author | "Ma X.L."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/author | "Huang S.H."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/author | "Geng Z."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/author | "Zhai L.K."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/pages | "453-465"xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/title | "Up-regulation of c-Jun NH2-terminal kinase-interacting protein 3 (JIP3) contributes to BDNF-enhanced neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/26303065 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26303065 |
| http://purl.uniprot.org/citations/26303065 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26303065 |
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| http://purl.uniprot.org/uniprot/#_P21237-mappedCitation-26303065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26303065 |
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| http://purl.uniprot.org/uniprot/A6K5V7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26303065 |