http://purl.uniprot.org/citations/26303528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/26303528 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding how transcriptional regulators are themselves controlled is important in attaining a complete picture of the intracellular effects that follow signaling cascades during early development and cell-restricted differentiation. We have addressed this issue by focusing on the regulation of EKLF/KLF1, a zinc finger transcription factor that plays a necessary role in the global regulation of erythroid gene expression. Using biochemical affinity purification, we have identified the DEK oncoprotein as a critical factor that interacts with an essential upstream enhancer element of the EKLF promoter and exerts a positive effect on EKLF levels. This element also binds a core set of erythroid transcription factors, suggesting that DEK is part of a tissue-restricted enhanceosome that contains BMP4-dependent and -independent components. Together with local enrichment of properly coded histones and an open chromatin domain, optimal transcriptional activation of the EKLF locus can be established."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00382-15"xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Bieker J.J."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Baron M.H."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Soni S."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Lohmann F."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Dangeti M."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/author | "Planutis A."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/pages | "3726-3738"xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/title | "The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells."xsd:string |
http://purl.uniprot.org/citations/26303528 | http://purl.uniprot.org/core/volume | "35"xsd:string |
http://purl.uniprot.org/citations/26303528 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26303528 |
http://purl.uniprot.org/citations/26303528 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26303528 |
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