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| http://purl.uniprot.org/citations/26304727 | http://www.w3.org/2000/01/rdf-schema#comment | "Embryonic epithelia have a remarkable ability to rapidly repair wounds. A supracellular actomyosin cable around the wound coordinates cellular movements and promotes wound closure. Actomyosin cable formation is accompanied by junctional rearrangements at the wound margin. We used in vivo time-lapse quantitative microscopy to show that clathrin, dynamin, and the ADP-ribosylation factor 6, three components of the endocytic machinery, accumulate around wounds in Drosophila melanogaster embryos in a process that requires calcium signaling and actomyosin contractility. Blocking endocytosis with pharmacological or genetic approaches disrupted wound repair. The defect in wound closure was accompanied by impaired removal of E-cadherin from the wound edge and defective actomyosin cable assembly. E-cadherin overexpression also resulted in reduced actin accumulation around wounds and slower wound closure. Reducing E-cadherin levels in embryos in which endocytosis was blocked rescued actin localization to the wound margin. Our results demonstrate a central role for endocytosis in wound healing and indicate that polarized E-cadherin endocytosis is necessary for actomyosin remodeling during embryonic wound repair."xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201501076"xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/author | "Lee D.M."xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/author | "Harris T.J."xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/author | "Fernandez-Gonzalez R."xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/author | "Hunter M.V."xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/pages | "801-816"xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/title | "Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair."xsd:string |
| http://purl.uniprot.org/citations/26304727 | http://purl.uniprot.org/core/volume | "210"xsd:string |
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