| http://purl.uniprot.org/citations/26308373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26308373 | http://www.w3.org/2000/01/rdf-schema#comment | "The serine/arginine-rich splicing actor 4 (SRSF4) is essential for pre-mRNA splicing and can influence alternative-splice-site choice. Little is known about the specific function of this gene in the reproductive system, although a recent study identified a SRSF4 polymorphism significantly associated with a decreased risk of non-obstructive azoospermia in Chinese men. We previously found that the expression of Srsf4 was up-regulated in the testes of Sertoli-cell-selective androgen receptor knockout (S-Ar(-/y)) mice compared to wild-type mice using digital gene expression analysis. In this study, we confirmed and extended the selective gene expression data: SRSF4 was mainly located in the nucleus of Sertoli cells, and Srsf4 expression in the Sertoli-cell-derived cell line TM4 is down-regulation by testosterone. Moreover, androgen receptor directly binds the androgen-responsive element of the Srsf4 promoter. Taken together, these results demonstrate that Srsf4 is a direct downstream target of the androgen receptor in mouse Sertoli cells."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.org/dc/terms/identifier | "doi:10.1002/mrd.22576"xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Lin S."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Luo M."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Ma Q."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Jiang Z."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/author | "Gui Y."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/name | "Mol Reprod Dev"xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/pages | "976-985"xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/title | "Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells."xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/26308373 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26308373 |
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