| http://purl.uniprot.org/citations/26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26314893 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesEnthesitis-related arthritis (ERA) is the most common form of juvenile idiopathic arthritis (JIA) in the Asian and Indian populations. The presence of HLA-B27 has a strong association with JIA-ERA similar to that with adult ankylosing spondylitis (AS). The HLA-B27gene is highly polymorphic. Susceptibility to AS varies between different HLA-B27 subtypes; data on the relationship of susceptibility to JIA-ERA with HLA-B27 types are scant. In this study, we determined HLA-B27 subtypes in patients with JIA-ERA and AS to find out whether there is any difference in the HLA-B27 subtypes prevalent in these two diseases.MethodsGenomic DNA from 135 patients with JIA-ERA and 121 with AS was tested for the presence of HLA-B27. In patients testing positive, HLA-B27subtyping was done by sequencing a genomic region that contained second and third exons and the intervening intron of this gene; this method permitted identification of common HLA-B27 subtypes (HLA-B*27:01 to HLA-B*27:09).ResultsOne hundred and seven (79%) patients with JIA-ERA and 102 (84%) patients with AS tested positive for HLA-B27. In both groups, HLA-B*27:05 and HLA-B*27:04 were the common subtypes; some patients had HLA-B*27:07(7.4%) and HLA-B*27:18. Patients with JIA-ERA had a higher frequency of HLA-B*27:05 than those with AS (70% vs. 57%, p=0.047), and a lower frequency of HLA-B*27:04 (21% vs. 36%, p=0.018).ConclusionsHLA-B*27:05 and HLA-B*27:04 were the most common HLA-27 subtypes in both JIA-ERA and AS. However, HLA-B*27:05 was more frequent and HLA-B*27:04 was less frequent in JIA-ERA. It is possible that HLA-B*27:05 being the ancestral HLA-27 subtype leads to expression of disease early in life."xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/author | "Aggarwal A."xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/author | "Srivastava R."xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/author | "Aggarwal R."xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/author | "Agnihotry S."xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/author | "Bajpai P."xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/name | "Clin Exp Rheumatol"xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/pages | "931-935"xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/title | "HLA-B27 subtypes in enthesitis-related arthritis category of juvenile idiopathic arthritis and ankylosing spondylitis in northern India."xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/26314893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26314893 |
| http://purl.uniprot.org/citations/26314893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A068B2J5-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A068B2Z1-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A068B6T8-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |
| http://purl.uniprot.org/uniprot/#_A0A089PAU6-mappedCitation-26314893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26314893 |