| http://purl.uniprot.org/citations/26318878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26318878 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic lymphocytic leukemia (CLL) is a clonal disease of B lymphocytes manifesting as an absolute lymphocytosis in the blood. However, not all lymphocytoses are leukemic. In addition, first-degree relatives of CLL patients have an ~15 % chance of developing a precursor condition to CLL termed monoclonal B cell lymphocytosis (MBL), and distinguishing CLL and MBL B lymphocytes from normal B cell expansions can be a challenge. Therefore, we selected FMOD, CKAP4, PIK3C2B, LEF1, PFTK1, BCL-2, and GPM6a from a set of genes significantly differentially expressed in microarray analyses that compared CLL cells with normal B lymphocytes and used these to determine whether we could discriminate CLL and MBL cells from B cells of healthy controls. Analysis with receiver operating characteristics and Bayesian relevance determination demonstrated good concordance with all panel genes. Using a random forest classifier, the seven-gene panel reliably distinguished normal polyclonal B cell populations from expression patterns occurring in pre-CLL and CLL B cell populations with an error rate of 2 %. Using Bayesian learning, the expression levels of only two genes, FMOD and PIK3C2B, correctly distinguished 100 % of CLL and MBL cases from normal polyclonal and mono/oligoclonal B lymphocytes. Thus, this study sets forth effective computational approaches that distinguish MBL/CLL from normal B lymphocytes. The findings also support the concept that MBL is a CLL precursor."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12026-015-8688-3"xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Paul S."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Moreno C."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Kolitz J.E."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "McCarthy B.A."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Rai K.R."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Wang X.P."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Chiorazzi N."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Lesser M."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Yan X.J."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Ferrarini M."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Bennett F."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Allen S.L."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Boyle E."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Tipping M."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Rawstron A.C."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Cutrona G."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Messmer B.T."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Yancopoulos S."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/author | "Catera R."xsd:string |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26318878 | http://purl.uniprot.org/core/name | "Immunol Res"xsd:string |