| http://purl.uniprot.org/citations/26319697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26319697 | http://www.w3.org/2000/01/rdf-schema#comment | "Thyroid hormone is a well-known regulator of brain, lung and kidney development and function. However, the molecular mechanisms by which the hormone exerts its function have remained largely enigmatic, and only a limited set of target genes have been identified in these tissues. Using a mouse model with a mutation in thyroid hormone receptor α1 (TRα1), we here demonstrate that the expression of carbonic anhydrase 4 in lung and brain of the adult animal depends on intact TRα1 signaling. In the kidney, carbonic anhydrase 4 mRNA and protein are not affected by the mutant TRα1, but are acutely repressed by thyroid hormone. However, neither lung function--as measured by respiration rate and oxygen saturation--nor urine pH levels were affected by altered carbonic anhydrase 4 levels, suggesting that other carbonic anhydrases are likely to compensate. Taken together, our findings identify a previously unknown marker of TRα1 action in brain and lung, and provide a novel negatively regulated target gene to assess renal thyroid hormone status."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2015.08.017"xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/author | "Vennstrom B."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/author | "Warner A."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/author | "Mittag J."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/author | "Vujovic M."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/author | "Dudazy-Gralla S."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/author | "Hard J."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/author | "Solsjo P."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/pages | "19-26"xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/title | "Thyroid hormone drives the expression of mouse carbonic anhydrase Car4 in kidney, lung and brain."xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://purl.uniprot.org/core/volume | "416"xsd:string |
| http://purl.uniprot.org/citations/26319697 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26319697 |
| http://purl.uniprot.org/citations/26319697 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26319697 |
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