| http://purl.uniprot.org/citations/26320999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26320999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26320999 | http://www.w3.org/2000/01/rdf-schema#comment | "The inflammatory caspases 1 and 11 are activated in response to different agonists and act independently to induce pyroptosis. In the context of IL-1β/IL-18 secretion, however, in vitro studies indicate that caspase-11 acts upstream of NLRP3 and caspase-1. By contrast, studying infection in vivo by the cytosol-invasive bacterium Burkholderia thailandensis, we find that caspase-1 activity is required upstream of caspase-11 to control infection. Caspase-1-activated IL-18 induces IFN-γ to prime caspase-11 and rapidly clear B. thailandensis infection. In the absence of IL-18, bacterial burdens persist, eventually triggering other signals that induce IFN-γ. Whereas IFN-γ was essential, endogenous type I interferons were insufficient to prime caspase-11. Although mice transgenic for caspase-4, the human ortholog of caspase-11, cleared B. thailandensis in vivo, they did not strictly require IFN-γ priming. Thus, caspase-1 provides priming signals upstream of caspase-11 but not caspase-4 during murine defense against a cytosol-invasive bacterium."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2015.07.016"xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2015.07.016"xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Buxbaum J.D."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Buxbaum J.D."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Kajiwara Y."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Kajiwara Y."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Ting J.P."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Ting J.P."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Miao E.A."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Miao E.A."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Coers J."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Coers J."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Mao D."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Mao D."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Aachoui Y."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Aachoui Y."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Aderem A."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Aderem A."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Leaf I.A."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/author | "Leaf I.A."xsd:string |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26320999 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |