| http://purl.uniprot.org/citations/26321222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26321222 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokines play a pivotal role in regulating tumor immunogenicity and antitumor immunity. IL-36γ is important for the IL-23/IL-17-dominated inflammation and anti-BCG Th1 immune responses. However, the impact of IL-36γ on tumor immunity is unknown. Here we found that IL-36γ stimulated CD8(+) T cells, NK cells, and γδ T cells synergistically with TCR signaling and/or IL-12. Importantly, IL-36γ exerted profound antitumor effects in vivo and transformed the tumor microenvironment in favor of tumor eradication. Furthermore, IL-36γ strongly increased the efficacy of tumor vaccination. Moreover, IL-36γ expression inversely correlated with the progression of human melanoma and lung cancer. Our study establishes a role of IL-36γ in promoting antitumor immune responses and suggests its potential clinical translation into cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2015.07.014"xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Tang P."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Wen W."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Feng C."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Xia R."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Zuo S."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Lv Q."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Zang S."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Weinstein A."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Denning T.L."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Stollings L."xsd:string |
| http://purl.uniprot.org/citations/26321222 | http://purl.uniprot.org/core/author | "Storkus W."xsd:string |