| http://purl.uniprot.org/citations/26324445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26324445 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell antigen receptor (BCR) signaling is critical for B cell development and activation. Using mass spectrometry, we identified a protein kinase D-interacting substrate of 220 kD (Kidins220)/ankyrin repeat-rich membrane-spanning protein (ARMS) as a novel interaction partner of resting and stimulated BCR. Upon BCR stimulation, the interaction increases in a Src kinase-independent manner. By knocking down Kidins220 in a B cell line and generating a conditional B cell-specific Kidins220 knockout (B-KO) mouse strain, we show that Kidins220 couples the BCR to PLCγ2, Ca(2+), and extracellular signal-regulated kinase (Erk) signaling. Consequently, BCR-mediated B cell activation was reduced in vitro and in vivo upon Kidins220 deletion. Furthermore, B cell development was impaired at stages where pre-BCR or BCR signaling is required. Most strikingly, λ light chain-positive B cells were reduced sixfold in the B-KO mice, genetically placing Kidins220 in the PLCγ2 pathway. Thus, our data indicate that Kidins220 positively regulates pre-BCR and BCR functioning."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20141271"xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Brummer T."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Dengjel J."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Cesca F."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Hobeika E."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Schamel W.W."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Seidl M."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Minguet S."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Sprenger A."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Fiala G.J."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Satapathy A."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Janowska I."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Plum T."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/author | "Prutek F."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/pages | "1693-1708"xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/title | "Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation."xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://purl.uniprot.org/core/volume | "212"xsd:string |
| http://purl.uniprot.org/citations/26324445 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26324445 |
| http://purl.uniprot.org/citations/26324445 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26324445 |
| http://purl.uniprot.org/uniprot/#_A0A076N1C3-mappedCitation-26324445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324445 |