| http://purl.uniprot.org/citations/26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26324895 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hippo (Hpo) pathway is a highly conserved tumor suppressor network that restricts developmental tissue growth and regulates stem cell proliferation and differentiation. At the heart of the Hpo pathway is the progrowth transcriptional coactivator Yorkie [Yki-Yes-activated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) in mammals]. Yki activity is restricted through phosphorylation by the Hpo/Warts core kinase cascade, but increasing evidence indicates that core kinase-independent modes of regulation also play an important role. Here, we examine Yki regulation in the Drosophila larval central nervous system and uncover a Hpo/Warts-independent function for the tumor suppressor kinase liver kinase B1 (LKB1) and its downstream effector, the energy sensor AMP-activated protein kinase (AMPK), in repressing Yki activity in the central brain/ventral nerve cord. Although the Hpo/Warts core cascade restrains Yki in the optic lobe, it is dispensable for Yki target gene repression in the late larval central brain/ventral nerve cord. Thus, we demonstrate a dramatically different wiring of Hpo signaling in neighboring cell populations of distinct developmental origins in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1505512112"xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/author | "Aerne B.L."xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/author | "Tapon N."xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/author | "Gailite I."xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/pages | "E5169-78"xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/title | "Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/26324895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26324895 |
| http://purl.uniprot.org/citations/26324895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFW0-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY2-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHD4-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI37-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6M4-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7W1-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6I1-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K784-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A1ZBL5-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A1ZBL7-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |
| http://purl.uniprot.org/uniprot/#_A1ZBL9-mappedCitation-26324895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26324895 |