| http://purl.uniprot.org/citations/26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26327117 | http://www.w3.org/2000/01/rdf-schema#comment | "microRNA-142 (miR-142) is an important regulator of many biological processes and associated signaling pathways during embryonic development, homeostasis and disease. The miR-142 hairpin gives rise to the "guide strand" miR-142-3p and the sister "passenger" strand miR-142-5p. miR-142-3p has been shown to play critical, non-redundant functions in the development of the hematopoietic lineage. We have recently reported that miR-142-3p is critical for the control of Wnt signaling in the mesenchyme of the developing lung. miR-142-5p has been proposed to control adaptive growth in cardiomyocytes postnatally and its increase is associated with extensive apoptosis and cardiac dysfunction in a murine heart failure model. Using homologous recombination, we now report the generation and validation of miR-142-null mice. miR-142-null mice show a significant decrease in th expression levels of both the 3p and 5p isoforms. The expression of Bzrap1, a gene immediately flanking miR-142 is not altered while the expression of a long non-coding RNA embedded within the miR-142 gene is decreased. miR-142-null newborn pups appear normal and are normally represented indicating absence of embryonic lethality. At embryonic day 18.5, miR-142-null lungs display increased Wnt signaling associated with the up-regulation of Apc and p300, two previously reported targets of miR-142-3p and -5p, respectively. Adult miR-142-null animals display impaired hematopoietic lineage formation identical to previously reported miR-142 gene trap knockdown mice. We report, for the first time, the homologous recombination-based miR-142-null mice that will be useful for the scientific community working on the diverse biological functions of miR-142."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0136913"xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "Shrestha A."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "Chao C.M."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "Barreto G."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "Bellusci S."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "Carraro G."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "Rizvanov A."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "El Agha E."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/author | "Mukhametshina R."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/pages | "e0136913"xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/title | "Generation and Validation of miR-142 Knock Out Mice."xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26327117 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26327117 |
| http://purl.uniprot.org/citations/26327117 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26327117 |
| http://purl.uniprot.org/uniprot/#_A0A087WPR8-mappedCitation-26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26327117 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26327117 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNN6-mappedCitation-26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26327117 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26327117 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26327117 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RQ52-mappedCitation-26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26327117 |
| http://purl.uniprot.org/uniprot/#_F7CD74-mappedCitation-26327117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26327117 |