| http://purl.uniprot.org/citations/26327203 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26327203 | http://www.w3.org/2000/01/rdf-schema#comment | "The metalloproteinase SAS1B [ovastacin, ASTL, astacin-like] was immunolocalized on the oolemma of ovulated human oocytes and in normal ovaries within the pool of growing oocytes where SAS1B protein was restricted to follicular stages spanning the primary-secondary follicle transition through ovulation. Gene-specific PCR and immunohistochemical studies revealed ASTL messages and SAS1B protein in both endometrioid [74%] and malignant mixed Mullerian tumors (MMMT) [87%] of the uterus. A MMMT-derived cell line, SNU539, expressed cell surface SAS1B that, after binding polyclonal antibodies, internalized into EEA1/LAMP1-positive early and late endosomes. Treatment of SNU539 cells with anti-SAS1B polyclonal antibodies caused growth arrest in the presence of active complement. A saporin-immunotoxin directed to SAS1B induced growth arrest and cell death. The oocyte restricted expression pattern of SAS1B among adult organs, cell-surface accessibility, internalization into the endocytic pathway, and tumor cell growth arrest induced by antibody-toxin conjugates suggest therapeutic approaches that would selectively target tumors while limiting adverse drug effects in healthy cells. The SAS1B metalloproteinase is proposed as a prototype cancer-oocyte tumor surface neoantigen for development of targeted immunotherapeutics with limited on-target/off tumor effects predicted to be restricted to the population of growing oocytes."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.4734"xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Thomas T."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Herr J.C."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Mandal A."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "D'Souza R.S."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Flickinger C.J."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Pollok B.A."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Jazaeri A.A."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Gougeon A."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Stoler M.H."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Bruns D.E."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Pires E.S."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Herr A.K."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Anderson-Knapp K.L."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/author | "Needham M.A."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/pages | "30194-30211"xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/title | "Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors."xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26327203 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26327203 |
| http://purl.uniprot.org/citations/26327203 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26327203 |