| http://purl.uniprot.org/citations/26332258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26332258 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that Cd3e-deficient mice adoptively transferred with CD4(+) T cells generate high numbers of T follicular helper (Tfh) cells, which go on to induce a strong B-cell and germinal center (GC) reaction. Here, we show that in this system, GC B cells display an altered distribution between the dark and light zones, and express low levels of activation-induced cytidine deaminase. Furthermore, GC B cells from Cd3e(-/-) mice accumulate fewer somatic mutations as compared with GC B cells from wild-type mice, and exhibit impaired affinity maturation and reduced differentiation into long-lived plasma cells. Reconstitution of Cd3e(-/-) mice with regulatory T (Treg) cells restored Tfh-cell numbers, GC B-cell numbers and B-cell distribution within dark and light zones, and the rate of antibody somatic mutations. Tfh-cell numbers and GC B-cell numbers and dynamics were also restored by pre-reconstitution of Cd3e(-/-) mice with Cxcr5(-/-) Treg cells or non-regulatory, memory CD4(+) T cells. Taken together, these findings underline the importance of a quantitatively regulated Tfh-cell response for an efficient and long-lasting serological response."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201545920"xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Foglierini M."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Lanzavecchia A."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Sallusto F."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Corti D."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Basso C."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Ronchi F."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Baumjohann D."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Preite S."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/author | "Fernandez Rodriguez B.M."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/pages | "3010-3021"xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/title | "Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells."xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/26332258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26332258 |
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| http://purl.uniprot.org/uniprot/#_A0A1L1SRC9-mappedCitation-26332258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26332258 |
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| http://purl.uniprot.org/uniprot/#_A6H6M1-mappedCitation-26332258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26332258 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-26332258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26332258 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4L2R0-mappedCitation-26332258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26332258 |