| http://purl.uniprot.org/citations/26333992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26333992 | http://www.w3.org/2000/01/rdf-schema#comment | "Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a type of membrane receptor with a seven-transmembrane structure. LGR4 is homologous to gonadotropin receptors, such as follicle-stimulating hormone receptor (Fshr) and luteinizing hormone/choriogonadotropin receptor (Lhcgr). Recently, it has been reported that Lgr4 is a membrane receptor for R-spondin ligands, which mediate Wnt/beta-catenin signaling. Defects of R-spondin homolog (Rspo1) and wingless-type MMTV integration site family, member 4 (Wnt4) cause masculinization of female gonads. We observed that Lgr4(-/-) female mice show abnormal development of the Wolffian ducts and somatic cells similar to that in the male gonads. Lgr4(-/-) female mice exhibited masculinization similar to that observed in Rspo1-deficient mice. In Lgr4(-/-) ovarian somatic cells, the expression levels of lymphoid enhancer-binding factor 1 (Lefl) and Axin2 (Axin2), which are target genes of Wnt/beta-catenin signaling, were lower than they were in wild-type mice. This study suggests that Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 and Wnt/beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.org/dc/terms/identifier | "doi:10.1095/biolreprod.114.123638"xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Goto T."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Satoh R."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Koizumi M."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Nishimori K."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Nawa A."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Oyama K."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Kida T."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Oe T."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Hidema S."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/author | "Yamakami Y."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/pages | "90"xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/title | "Lgr4 controls specialization of female gonads in mice."xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/26333992 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26333992 |
| http://purl.uniprot.org/citations/26333992 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26333992 |
| http://purl.uniprot.org/uniprot/#_A0A087WRU6-mappedCitation-26333992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26333992 |
| http://purl.uniprot.org/uniprot/#_A0A087WRA8-mappedCitation-26333992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26333992 |
| http://purl.uniprot.org/uniprot/#_A2ARI4-mappedCitation-26333992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26333992 |