| http://purl.uniprot.org/citations/26337479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26337479 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoarthritis (OA) is a whole-joint disease characterized by articular cartilage loss, tissue inflammation, abnormal bone formation and extracellular matrix (ECM) mineralization. Disease-modifying treatments are not yet available and a better understanding of osteoarthritis pathophysiology should lead to the discovery of more effective treatments. Gla-rich protein (GRP) has been proposed to act as a mineralization inhibitor and was recently shown to be associated with OA in vivo. Here, we further investigated the association of GRP with OA mineralization-inflammation processes. Using a synoviocyte and chondrocyte OA cell system, we showed that GRP expression was up-regulated following cell differentiation throughout ECM calcification, and that inflammatory stimulation with IL-1β results in an increased expression of COX2 and MMP13 and up-regulation of GRP. Importantly, while treatment of articular cells with γ-carboxylated GRP inhibited ECM calcification, treatment with either GRP or GRP-coated basic calcium phosphate (BCP) crystals resulted in the down-regulation of inflammatory cytokines and mediators of inflammation, independently of its γ-carboxylation status. Our results strengthen the calcification inhibitory function of GRP and strongly suggest GRP as a novel anti-inflammatory agent, with potential beneficial effects on the main processes responsible for osteoarthritis progression. In conclusion, GRP is a strong candidate target to develop new therapeutic approaches."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-015-2033-9"xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Ramos A."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Blanco F.J."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Magalhaes J."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Simes D.C."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Viegas C.S."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Vermeer C."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Cavaco S."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/author | "Rafael M.S."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/pages | "1051-1065"xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/title | "Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis."xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/26337479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26337479 |
| http://purl.uniprot.org/citations/26337479 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26337479 |
| http://purl.uniprot.org/uniprot/#_A0A067XJP8-mappedCitation-26337479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26337479 |
| http://purl.uniprot.org/uniprot/#_A0A067XJX6-mappedCitation-26337479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26337479 |
| http://purl.uniprot.org/uniprot/#_A0A067XKV3-mappedCitation-26337479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26337479 |
| http://purl.uniprot.org/uniprot/#_Q8WVF2-mappedCitation-26337479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26337479 |
| http://purl.uniprot.org/uniprot/A0A067XJX6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26337479 |
| http://purl.uniprot.org/uniprot/Q8WVF2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26337479 |
| http://purl.uniprot.org/uniprot/A0A067XKV3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26337479 |