| http://purl.uniprot.org/citations/26338045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26338045 | http://www.w3.org/2000/01/rdf-schema#comment | "Elucidation of the downstream targets regulated by the metastasis-suppressive miRNAs can shed light on the metastatic processes in prostate cancer (PCa). We conducted microarray analyses and found that miR-195 was significantly decreased in metastatic PCa. Low miR-195 expression is an independent prognostic factor for poor biochemical recurrence-free and overall survival. Forced expression of miR-195 in PCa cells drastically inhibits proliferation, migration and invasion in vitro and inhibits tumor growth and metastasis in vivo. BCOX1 is identified as a direct target of miR-195 in PCa, and is found to be drastically increased in metastatic PCa. BCOX1 knockdown phenotypically copies miR-195-induced phenotypes, whereas forced expression of BCOX1 reverses the effects of miR-195. Collectively, this is the first report unveils that loss of miR-195 expression and thus uncontrolled BCOX1 upregulation might drive PCa metastasis."xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13046-015-0209-7"xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/name | "J Exp Clin Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/pages | "91"xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/title | "MicroRNA-195 suppresses tumor cell proliferation and metastasis by directly targeting BCOX1 in prostate carcinoma."xsd:string |
| http://purl.uniprot.org/citations/26338045 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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