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http://purl.uniprot.org/citations/26338697http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26338697http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26338697http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26338697http://www.w3.org/2000/01/rdf-schema#comment"From December 2012 to February 2013, two outbreaks of acute respiratory disease caused by HAdV-7 were reported in China. We investigated possible transmission links between these two seemingly unrelated outbreaks by integration of epidemiological and whole-genome sequencing (WGS) data. WGS analyses showed that the HAdV-7 isolates from the two outbreaks were genetically indistinguishable; however, a 12 bp deletion in the virus-associated RNA gene distinguished the outbreak isolates from other HAdV-7 isolates. Outbreak HAdV-7 isolates demonstrated increased viral replication compared to non-outbreak associated HAdV-7 isolate. Epidemiological data supported that the first outbreak was caused by introduction of the novel HAdV-7 virus by an infected recruit upon arrival at the training base. Nosocomial transmission by close contacts was the most likely source leading to onset of the second HAdV-7 outbreak, establishing the apparent transmission link between the outbreaks. Our findings imply that in-hospital contact investigations should be encouraged to reduce or interrupt further spread of infectious agents when treating outbreak cases, and WGS can provide useful information guiding infection-control interventions."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.org/dc/terms/identifier"doi:10.1038/srep13617"xsd:string
http://purl.uniprot.org/citations/26338697http://purl.org/dc/terms/identifier"doi:10.1038/srep13617"xsd:string
http://purl.uniprot.org/citations/26338697http://purl.org/dc/terms/identifier"doi:10.1038/srep13617"xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Huang L."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Huang L."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Huang L."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li C."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li C."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li C."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li S."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li S."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li S."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/26338697http://purl.uniprot.org/core/author"Li Y."xsd:string