| http://purl.uniprot.org/citations/26339164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26339164 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite a low risk of liver failure and preserved liver function, non-cirrhotic hepatocellular carcinoma (HCC) has a poor prognosis. In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of AROS were measured in tumor and non-tumor tissues obtained from 283 non-cirrhotic HCC patients. AROS expression was exclusively up-regulated in recurrent tissues from the non-cirrhotic HCC patients (P = 0.015) and also in tumor tissues irrespective of tumor stage (P < 0.001) or BCLC stage (P < 0.001). High mRNA levels of AROS were statistically significantly associated with tumor stage (P < 0.001), BCLC stage (P = 0.007), alpha fetoprotein (AFP) level (P = 0.013), microvascular invasion (P = 0.001), tumor size (P = 0.036), and portal vein invasion (P = 0.005). Kaplan-Meir curve analysis demonstrated that HCC patients with higher AROS levels had shorter disease-free survival (DFS) in both the short-term (P < 0.001) and long-term (P = 0.005) compared to those with low AROS. Cox regression analysis demonstrated that AROS is a significant predictor for DFS along with large tumor size, tumor multiplicity, vascular invasion, and poor tumor differentiation, which are the known prognostic factors. In conclusion, AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.org/dc/terms/identifier | "doi:10.3346/jkms.2015.30.9.1253"xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Moon Y.H."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Wang H.J."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Park J.Y."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Choi K.Y."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Ahn K.S."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Kim G."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Lee K.G."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Kwon J.H."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Kang K.J."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/author | "Joh J.W."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/name | "J Korean Med Sci"xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/pages | "1253-1259"xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/title | "AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma."xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/26339164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26339164 |
| http://purl.uniprot.org/citations/26339164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26339164 |
| http://purl.uniprot.org/uniprot/#_Q86WX3-mappedCitation-26339164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26339164 |
| http://purl.uniprot.org/uniprot/Q86WX3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26339164 |