| http://purl.uniprot.org/citations/26339343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26339343 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer/testis (CT) antigens are normally expressed in testis and overexpressed in various tumor types. However, their biological function is largely unknown. OY-TES-1, one of cancer/testis (CT) antigens, is reported overexpression in hepatocellular carcinoma (HCC). And we assumed that OY-TES-1 contribute to oncogenesis and progression of HCC. In this study, we knocked down OY-TES-1 by small interference RNA (siRNA) in HCC cell lines (HepG2 and BEL-7404) to verify this assumption and evaluate its potential as therapeutic targets for HCC. We showed that down regulation of OY-TES-1 decreased cell growth, induced the G0/G1 arrest and apoptosis, and prevented migration and invasion in the two HCC cell lines. Further analysis revealed that down regulation of OY-TES-1 increased expression of apoptosis-regulated protein caspase-3, and decreased expression of cell cycle-regulated protein cyclin E, migration/invasion-regulated proteins MMP2 and MMP9. These findings may shed light on the gene therapy about the OY-TES-1 expression in HCC cells."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Luo B."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Shi L."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Xie X.X."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Zhang Q.M."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Hu Q.P."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Guo W.W."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/author | "Xiao S.W."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/name | "Int J Clin Exp Pathol"xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/pages | "7786-7797"xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/title | "Down-regulation of cancer/testis antigen OY-TES-1 attenuates malignant behaviors of hepatocellular carcinoma cells in vitro."xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/26339343 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26339343 |
| http://purl.uniprot.org/citations/26339343 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26339343 |
| http://purl.uniprot.org/uniprot/#_A0A140VJD6-mappedCitation-26339343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26339343 |
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| http://purl.uniprot.org/uniprot/#_B2R6Z8-mappedCitation-26339343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26339343 |
| http://purl.uniprot.org/uniprot/#_Q8NEB7-mappedCitation-26339343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26339343 |
| http://purl.uniprot.org/uniprot/B2R6Z8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26339343 |
| http://purl.uniprot.org/uniprot/B4DY68 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26339343 |
| http://purl.uniprot.org/uniprot/A0A140VJD6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26339343 |