| http://purl.uniprot.org/citations/26339988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26339988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26339988 | http://www.w3.org/2000/01/rdf-schema#comment | "Axon injury triggers a series of changes in the axonal cytoskeleton that are prerequisites for effective axon regeneration. In Caenorhabditis elegans the signaling protein Exchange Factor for ARF-6 (EFA-6) is a potent intrinsic inhibitor of axon regrowth. Here we show that axon injury triggers rapid EFA-6-dependent inhibition of axonal microtubule (MT) dynamics, concomitant with relocalization of EFA-6. EFA-6 relocalization and axon regrowth inhibition require a conserved 18-aa motif in its otherwise intrinsically disordered N-terminal domain. The EFA-6 N-terminus binds the MT-associated proteins TAC-1/Transforming-Acidic-Coiled-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for regenerative growth cone formation, and which act downstream of EFA-6. After injury TAC-1 and EFA-6 transiently relocalize to sites marked by the MT minus end binding protein PTRN-1/Patronin. We propose that EFA-6 acts as a bifunctional injury-responsive regulator of axonal MT dynamics, acting at the cell cortex in the steady state and at MT minus ends after injury."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.08695"xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.08695"xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Chisholm A.D."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Chisholm A.D."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Boxem M."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Boxem M."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Koorman T."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Koorman T."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Chuang M."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/author | "Chuang M."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/title | "Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/title | "Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase."xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/26339988 | http://purl.uniprot.org/core/volume | "4"xsd:string |