| http://purl.uniprot.org/citations/26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26344761 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon amino acid (AA) starvation and TOR inactivation, plasma-membrane-localized permeases rapidly undergo ubiquitination and internalization via the vacuolar protein sorting/multivesicular body (VPS-MVB) pathway and are degraded in the yeast vacuole. We now show that specific Golgi proteins are also directed to the vacuole under these conditions as part of a Golgi quality-control (GQC) process. The degradation of GQC substrates is dependent upon ubiquitination by the defective-for-SREBP-cleavage (DSC) complex, which was identified via genetic screening and includes the Tul1 E3 ligase. Using a model GQC substrate, GFP-tagged Yif1, we show that vacuolar targeting necessitates upregulation of the VPS pathway via proteasome-mediated degradation of the initial endosomal sorting complex required for transport, ESCRT-0, but not downstream ESCRT components. Thus, early cellular responses to starvation include the targeting of specific Golgi proteins for degradation, a phenomenon reminiscent of the inactivation of BTN1, the yeast Batten disease gene ortholog."xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.08.026"xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/author | "Schuldiner M."xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/author | "Gerst J.E."xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/author | "Kama R."xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/author | "Chuartzman S.G."xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/author | "Dobzinski N."xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/pages | "1876-1886"xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/title | "Starvation-Dependent Regulation of Golgi Quality Control Links the TOR Signaling and Vacuolar Protein Sorting Pathways."xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/26344761 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26344761 |
| http://purl.uniprot.org/citations/26344761 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26344761 |
| http://purl.uniprot.org/uniprot/#_P53845-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_P13134-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_P38182-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_P15731-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_P15732-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_Q08144-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_Q08232-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_Q12015-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_Q12229-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |
| http://purl.uniprot.org/uniprot/#_Q03322-mappedCitation-26344761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26344761 |