| http://purl.uniprot.org/citations/26345899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26345899 | http://www.w3.org/2000/01/rdf-schema#comment | "Alopecia areata (AA) is a common disease, which causes hair loss in humans. AA has a genetically complex inheritance. This study investigated the possible correlations between single nucleotide polymorphisms (SNPs) in the promoter regions of the chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) genes and the development of AA in the Korean population. Two hundred and thirty-five AA patients and 240 control subjects were recruited. The specific SNPs occurring in the promoter regions of the CXCL1 and CXCL2 genes (rs3117604, -429C/T and rs3806792, -264T/C, respectively) were genotyped. All data obtained was evaluated using the SNPStats, SPSS 18.0, and the Haploview v.4.2 software platforms. The Odd's ratios (OR), 95% confidence intervals (CI), and P values were calculated using multiple logistic regression models. Analyses of the genetic sequences obtained revealed a significant correlation between the two SNPs and the development of AA (rs3117604, P = 0.0009 in co-dominant model 1, P = 0.01 in co-dominant model 2, P = 0.004 in the dominant model, P = 0.005 in the log-additive model, P = 0.012 in allele distribution; rs3806792, P = 0.036 in co-dominant model 2, P = 0.0046 in the log-additive model). The TT and CC haplotypes were also observed to show a significant association with increased risk of AA (TT haplotype, P = 0.0018; CC haplotype, P = 0.0349). Our data suggests that the CXCL1 and CXCL2 genes may be associated with AA susceptibility."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.org/dc/terms/identifier | "doi:10.4238/2015.august.14.29"xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Chung J.H."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Kang S.W."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Park H.J."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Ko H.Y."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Byun S.H."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Lim D.J."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Baik H.H."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Sim W.Y."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Lew B.L."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/author | "Baek D.G."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/name | "Genet Mol Res"xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/pages | "9667-9674"xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/title | "Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population."xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/26345899 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26345899 |
| http://purl.uniprot.org/citations/26345899 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26345899 |
| http://purl.uniprot.org/uniprot/#_P19875-mappedCitation-26345899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26345899 |
| http://purl.uniprot.org/uniprot/#_P09341-mappedCitation-26345899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26345899 |
| http://purl.uniprot.org/uniprot/#_Q6LD33-mappedCitation-26345899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26345899 |
| http://purl.uniprot.org/uniprot/#_Q6LD34-mappedCitation-26345899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26345899 |