| http://purl.uniprot.org/citations/26348328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26348328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26348328 | http://www.w3.org/2000/01/rdf-schema#comment | "Pathogens utilize effectors to suppress basal plant defense known as PTI (Pathogen-associated molecular pattern-triggered immunity). However, our knowledge of PTI suppression by filamentous plant pathogens, i.e. fungi and oomycetes, remains fragmentary. Previous work revealed that the co-receptor BAK1/SERK3 contributes to basal immunity against the potato pathogen Phytophthora infestans. Moreover BAK1/SERK3 is required for the cell death induced by P. infestans elicitin INF1, a protein with characteristics of PAMPs. The P. infestans host-translocated RXLR-WY effector AVR3a is known to supress INF1-mediated cell death by binding the plant E3 ligase CMPG1. In contrast, AVR3aKI-Y147del, a deletion mutant of the C-terminal tyrosine of AVR3a, fails to bind CMPG1 and does not suppress INF1-mediated cell death. Here, we studied the extent to which AVR3a and its variants perturb additional BAK1/SERK3-dependent PTI responses in N. benthamiana using the elicitor/receptor pair flg22/FLS2 as a model. We found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, we discovered that AVR3a associates with the Dynamin-Related Protein 2 (DRP2), a plant GTPase implicated in receptor-mediated endocytosis. Interestingly, silencing of DRP2 impaired ligand-induced FLS2 internalization but did not affect internalization of the growth receptor BRI1. Our results suggest that AVR3a associates with a key cellular trafficking and membrane-remodeling complex involved in immune receptor-mediated endocytosis. We conclude that AVR3a is a multifunctional effector that can suppress BAK1/SERK3-mediated immunity through at least two different pathways."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0137071"xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0137071"xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Bos J.I."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Bos J.I."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Bozkurt T.O."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Bozkurt T.O."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Jones A.M."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Jones A.M."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Kamoun S."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Kamoun S."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Schornack S."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Schornack S."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Sklenar J."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Sklenar J."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Chaparro-Garcia A."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Chaparro-Garcia A."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Petre B."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Petre B."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Schwizer S."xsd:string |
| http://purl.uniprot.org/citations/26348328 | http://purl.uniprot.org/core/author | "Schwizer S."xsd:string |