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http://purl.uniprot.org/citations/26354056http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26354056http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

Newer P2Y12 inhibitors, such as prasugrel and ticagrelor, have greater antiplatelet efficacy but may increase the risk of bleeding. In this study, we compared the pharmacodynamic efficacy of prasugrel and ticagrelor in East Asian patients with acute coronary syndrome (ACS).

Methods

We selected 83 ACS patients undergoing percutaneous coronary intervention who were discharged with 90 mg ticagrelor twice daily (n = 24), 10 mg prasugrel daily (n = 39) or 5 mg prasugrel daily (n = 20). After 2 to 4 weeks, on-treatment platelet reactivity (OPR) was assessed in terms of P2Y12 reaction units (PRUs) using the VerifyNow P2Y12 assay (Accumetrics). We compared East Asian (85 < PRU ≤ 275) and Caucasian (85 < PRU ≤ 208) criteria for assessing the therapeutic window of OPR.

Results

OPR was lowest in the ticagrelor group, followed by the 10 mg prasugrel and 5 mg prasugrel groups (49.1 ± 29.9 vs. 83.7 ± 57.1 vs. 168.5 ± 60.8, respectively; p < 0.001). The 5 mg prasugrel group had the highest proportion of patients with OPR values within the therapeutic window, followed by the 10 mg prasugrel and ticagrelor groups (90.0% vs. 46.2% vs. 12.5%, respectively; p < 0.001 for East Asian criteria; 60.0% vs. 43.6% vs. 12.5%, respectively; p < 0.001 for Caucasian criteria).

Conclusions

Short-term administration of 5 mg prasugrel facilitated maintenance within the therapeutic window of OPR compared with the 10 mg prasugrel and ticagrelor groups. Thus, 5 mg prasugrel daily may be the optimal antiplatelet regimen for stabilized East Asian ACS patients."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.org/dc/terms/identifier"doi:10.3904/kjim.2015.30.5.620"xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Lee J.H."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Lee J.W."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Lee S.H."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Kim J.Y."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Park S.W."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Yoon J."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Park B."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Kang Y.S."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Ahn S.G."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Yoo B.S."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Ahn M.S."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/author"Youn Y.J."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/name"Korean J Intern Med"xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/pages"620-628"xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/title"A pharmacodynamic study of the optimal P2Y12 inhibitor regimen for East Asian patients with acute coronary syndrome."xsd:string
http://purl.uniprot.org/citations/26354056http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/26354056http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26354056
http://purl.uniprot.org/citations/26354056http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26354056
http://purl.uniprot.org/uniprot/#_B2RE67-mappedCitation-26354056http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26354056
http://purl.uniprot.org/uniprot/#_A0A2H4P6E7-mappedCitation-26354056http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26354056
http://purl.uniprot.org/uniprot/#_B4E183-mappedCitation-26354056http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26354056
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