| http://purl.uniprot.org/citations/26354229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26354229 | http://www.w3.org/2000/01/rdf-schema#comment | "Altered transforming growth factor-β (TGF-β) signalling has been implicated in tumour development and progression. However, the molecular mechanism behind this alteration is poorly understood. Here we show that profilin-2 (Pfn2) increases Smad2 and Smad3 expression via an epigenetic mechanism, and that profilin-2 and Smad expression correlate with an unfavourable prognosis of lung cancer patients. Profilin-2 overexpression promotes, whereas profilin-2 knockdown drastically reduces, lung cancer growth and metastasis. We show that profilin-2 suppresses the recruitment of HDAC1 to Smad2 and Smad3 promoters by preventing nuclear translocation of HDAC1 through protein-protein interaction at the C terminus of both proteins, leading to the transcriptional activation of Smad2 and Smad3. Increased Smad2 and Smad3 expression enhances TGF-β1-induced EMT and production of the angiogenic factors VEGF and CTGF. These findings reveal a new regulatory mechanism of TGF-β1/Smad signalling, and suggest a potential molecular target for the development of anticancer drugs."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9230"xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/author | "Guo X.J."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/author | "Wang D.M."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/author | "Song J.G."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/author | "Ding W.Q."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/author | "Yuan X.W."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/author | "Tang Y.N."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/pages | "8230"xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/title | "Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis."xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26354229 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26354229 |
| http://purl.uniprot.org/citations/26354229 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26354229 |
| http://purl.uniprot.org/uniprot/#_B4DNH1-mappedCitation-26354229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26354229 |
| http://purl.uniprot.org/uniprot/#_G5E9Q6-mappedCitation-26354229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26354229 |
| http://purl.uniprot.org/uniprot/#_P35080-mappedCitation-26354229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26354229 |
| http://purl.uniprot.org/uniprot/G5E9Q6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26354229 |
| http://purl.uniprot.org/uniprot/P35080 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26354229 |
| http://purl.uniprot.org/uniprot/B4DNH1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26354229 |