| http://purl.uniprot.org/citations/26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26359358 | http://www.w3.org/2000/01/rdf-schema#comment | "Leptin, a major adipocytokine produced by adipocytes, is emerging as a key molecule linking obesity with breast cancer therefore, it is important to find effective strategies to antagonize oncogenic effects of leptin to disrupt obesity-cancer axis. Here, we examine the potential of honokiol (HNK), a bioactive polyphenol from Magnolia grandiflora, as a leptin-antagonist and systematically elucidate the underlying mechanisms. HNK inhibits leptin-induced epithelial-mesenchymal-transition (EMT), and mammosphere-formation along with a reduction in the expression of stemness factors, Oct4 and Nanog. Investigating the downstream mediator(s), that direct leptin-antagonist actions of HNK; we discovered functional interactions between HNK, LKB1 and miR-34a. HNK increases the expression and cytoplasmic-localization of LKB1 while HNK-induced SIRT1/3 accentuates the cytoplasmic-localization of LKB1. We found that HNK increases miR-34a in LKB1-dependent manner as LKB1-silencing impedes HNK-induced miR-34a which can be rescued by LKB1-overexpression. Finally, an integral role of miR-34a is discovered as miR-34a mimic potentiates HNK-mediated inhibition of EMT, Zeb1 expression and nuclear-localization, mammosphere-formation, and expression of stemness factors. Leptin-antagonist actions of HNK are further enhanced by miR-34a mimic whereas miR-34a inhibitor results in inhibiting HNK's effect on leptin. These data provide evidence for the leptin-antagonist potential of HNK and reveal the involvement of LKB1 and miR-34a."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.4937"xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/author | "Sharma D."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/author | "Arbiser J.L."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/author | "Saxena N.K."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/author | "Nagalingam A."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/author | "Bonner M.Y."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/author | "Avtanski D.B."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/pages | "29947-29962"xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/title | "Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26359358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26359358 |
| http://purl.uniprot.org/citations/26359358 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26359358 |
| http://purl.uniprot.org/uniprot/#_D4P556-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4C7-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4D1-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_A6YR18-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_Q15831-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_Q59FA7-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_Q5ZEZ1-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_Q9HBS3-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |
| http://purl.uniprot.org/uniprot/#_Q9NS52-mappedCitation-26359358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26359358 |