| http://purl.uniprot.org/citations/26367487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26367487 | http://www.w3.org/2000/01/rdf-schema#comment | "miR-21, which is a putative tumor onco-miR and frequently overexpressed microRNA in various tumors, has been linked to tumor progression through targeting of tumor-suppressor genes. In this study, we sought to determine whether miR-21 has any role on tumor progression of salivary adenoid cystic carcinoma (SACC) and the possible mechanisms. We found that the level of miR-21 expression was significantly higher in SACC than that in normal salivary tissues, and it is also higher in tumors with metastasis than that without metastasis. Using an anti-miR-21 inhibitor in an in vitro model, downregulation of miR-21 significantly decreased the capacity of invasion and migration of SACC cells, whereas a pre-miR-21 increased the capacity of invasion and migration of SACC cells. To explore the potential mechanisms by which miR-21 regulate invasion and migration, we identified one direct miR-21 target gene, programmed cell death 4 (PDCD4), which has been implicated in invasion and metastasis. The suppression of miR-21 in metastatic SACC-LM cells significantly increased the report activity of PDCD4 promoter and the expression of PDCD4 protein. This subsequently resulted in downregulation of the p-STAT3 protein. The level of miR-21 expression positively related to the expression of PDCD4 protein and negatively related to the expression of p-STAT3 protein in SACC specimens, respectively, indicating the potential role of the STAT3-miR-21-PDCD4 pathway in these tumors. Dysregulation of miR-21 has an important role in tumor growth and invasion by targeting PDCD4. Therefore, suppression of miR-21 may provide a potential approach for the treatment of advanced SACC patients."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.org/dc/terms/identifier | "doi:10.1038/labinvest.2015.105"xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Cao J."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Wu Y.C."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Hu S.S."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Ling Z.Q."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Jiang L.H."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Lu X.X."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Ge M.H."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Hong L.L."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/author | "Hou X.X."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/name | "Lab Invest"xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/pages | "1398-1408"xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/title | "miR-21 regulates tumor progression through the miR-21-PDCD4-Stat3 pathway in human salivary adenoid cystic carcinoma."xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/26367487 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26367487 |
| http://purl.uniprot.org/citations/26367487 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26367487 |
| http://purl.uniprot.org/uniprot/#_B7ZA24-mappedCitation-26367487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26367487 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-26367487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26367487 |