| http://purl.uniprot.org/citations/26371861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26371861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26371861 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypothemycin, a resorcylic acid lactone polyketide, has been shown to inhibit oncogenic ras-transformation and T cell activation. In the present study, we investigated the effect of hypothemycin on tumor necrosis factor-α (TNF-α) production in macrophages and the molecular mechanisms involved in this effect. Hypothemycin potently suppressed the TNF-α production without affecting nitric oxide production in lipopolysaccharide (LPS)-stimulated macrophages. However, hypothemycin had no effect on the activity of TNF-α-converting enzyme, a key enzyme for converting membrane-bound pro-TNF-α into soluble TNF-α. Further study demonstrated that the stability of TNF-α mRNA was decreased by hypothemycin treatment. In addition, hypothemycin suppressed LPS-induced phosphorylation of p38 MAPK and ERK. Moreover, knockdown of tristetraprolin (TTP), which is an important trans-acting regulator of TNF-α mRNA stability and downstream target of p38 MAPK and ERK, reversed hypothemycin-mediated inhibition of TNF-α mRNA expression. Collectively, our results suggest that hypothemycin suppresses TNF-α production by TTP-dependent destabilization of TNF-α mRNA and this is mediated, at least in part, by blocking the activation of p38 MAPK and ERK."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2015.08.030"xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2015.08.030"xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Park K.H."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Park K.H."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Yun J."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Yun J."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Kang J.S."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Kang J.S."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Lee M.Y."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Lee M.Y."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Oh S.J."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Oh S.J."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Lee C.W."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Lee C.W."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Han S.B."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Han S.B."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Kang M.R."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Kang M.R."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Yoon Y.D."xsd:string |
| http://purl.uniprot.org/citations/26371861 | http://purl.uniprot.org/core/author | "Yoon Y.D."xsd:string |