| http://purl.uniprot.org/citations/26373539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26373539 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasing evidence suggests that olfactory dysfunction is an endophenotype of schizophrenia, and thus the olfactory system can be studied both in relation to this sensory dysfunction and also as a means of examining pathophysiologic mechanisms of schizophrenia. In this study, we examined human olfactory neuroepithelial (ON) biopsy tissues and their in vitro culture cells for ligand-induced guanine nucleotide-binding protein (G protein) activation and downstream signaling. We assessed the binding of a nonhydrolyzable GTP analogue [(35)S]GTPγS binding to specific G protein subtypes in response to odorants, dopamine, or serotonin in ON cell membranes from matched schizophrenia-control subjects. In response to odorant mixtures, we found decreased [(35)S]GTPγS binding to Gαs/olf in schizophrenia patients. These changes were not mediated by mRNA expression of key molecules of G protein coupling, including adenylate cyclase III (ACIII), protein kinase A (PKA), protein kinase Cγ (PKCγ), or Gαs or Gαolf in ON cells or ON biopsy tissues. In contrast, dopamine (DA)- and serotonin (5HT)-induced S(35)-GTPγS binding to Gαs/olf and Gαq/11 were significantly increased in schizophrenia cases, while these parameters were strikingly reduced by in vitro treatment with antipsychotics. Patients with schizophrenia exhibit increases in electrolfactogram (EOG) recordings, suggesting enhanced odorant-induced activation. Our results of decreased odorant-induced G protein activation may point further downstream for underlying mechanisms for increased EOG measures. Increased G protein activation in response to DA and 5HT may suggest increased postreceptor DA or 5HT signaling as an additional mechanism of dopaminergic or serotonergic dysregulation in schizophrenia."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.org/dc/terms/identifier | "doi:10.1093/schbul/sbv129"xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Ray R."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Wang H.Y."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Gur R.E."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Hahn C.G."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Moberg P.J."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Turetsky B.I."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Borgmann-Winter K.E."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Rawson N.E."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/author | "Willis B.R."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/name | "Schizophr Bull"xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/pages | "377-385"xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/title | "Altered G Protein Coupling in Olfactory Neuroepithelial Cells From Patients With Schizophrenia."xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/26373539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26373539 |
| http://purl.uniprot.org/citations/26373539 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26373539 |
| http://purl.uniprot.org/uniprot/#_P0C617-mappedCitation-26373539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26373539 |
| http://purl.uniprot.org/uniprot/#_P0C7N1-mappedCitation-26373539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26373539 |
| http://purl.uniprot.org/uniprot/#_Q15619-mappedCitation-26373539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26373539 |
| http://purl.uniprot.org/uniprot/#_A4D2G3-mappedCitation-26373539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26373539 |
| http://purl.uniprot.org/uniprot/#_A6NND4-mappedCitation-26373539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26373539 |
| http://purl.uniprot.org/uniprot/#_P58170-mappedCitation-26373539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26373539 |