| http://purl.uniprot.org/citations/26378256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26378256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26378256 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic cilia are cell-surface projections critical for sensing the extracellular environment. Defects in cilia structure and function result in a broad range of developmental and sensory disorders. However, mechanisms that regulate the microtubule (MT)-based scaffold forming the cilia core are poorly understood. TOG domain array-containing proteins ch-TOG and CLASP are key regulators of cytoplasmic MTs. Whether TOG array proteins also regulate ciliary MTs is unknown. Here we identify the conserved Crescerin protein family as a cilia-specific, TOG array-containing MT regulator. We present the crystal structure of mammalian Crescerin1 TOG2, revealing a canonical TOG fold with conserved tubulin-binding determinants. Crescerin1's TOG domains possess inherent MT-binding activity and promote MT polymerization in vitro. Using Cas9-triggered homologous recombination in Caenorhabditis elegans, we demonstrate that the worm Crescerin family member CHE-12 requires TOG domain-dependent tubulin-binding activity for sensory cilia development. Thus, Crescerin expands the TOG domain array-based MT regulatory paradigm beyond ch-TOG and CLASP, representing a distinct regulator of cilia structure."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e15-08-0603"xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e15-08-0603"xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Das A."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Das A."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Wood C.C."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Wood C.C."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Dickinson D.J."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Dickinson D.J."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Slep K.C."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Slep K.C."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Goldstein B."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/author | "Goldstein B."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/pages | "4248-4264"xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/pages | "4248-4264"xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/title | "Crescerin uses a TOG domain array to regulate microtubules in the primary cilium."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/title | "Crescerin uses a TOG domain array to regulate microtubules in the primary cilium."xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/26378256 | http://purl.uniprot.org/core/volume | "26"xsd:string |