| http://purl.uniprot.org/citations/26385964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26385964 | http://www.w3.org/2000/01/rdf-schema#comment | "The 137 ribosomal protein genes (RPGs) of Saccharomyces provide a model for gene coregulation. We examined the positional and functional organization of their regulators (Rap1 [repressor activator protein 1], Fhl1, Ifh1, Sfp1, and Hmo1), the transcription machinery (TFIIB, TFIID, and RNA polymerase II), and chromatin at near-base-pair resolution using ChIP-exo, as RPGs are coordinately reprogrammed. Where Hmo1 is enriched, Fhl1, Ifh1, Sfp1, and Hmo1 cross-linked broadly to promoter DNA in an RPG-specific manner and demarcated by general minor groove widening. Importantly, Hmo1 extended 20-50 base pairs (bp) downstream from Fhl1. Upon RPG repression, Fhl1 remained in place. Hmo1 dissociated, which was coupled to an upstream shift of the +1 nucleosome, as reflected by the Hmo1 extension and core promoter region. Fhl1 and Hmo1 may create two regulatable and positionally distinct barriers, against which chromatin remodelers position the +1 nucleosome into either an activating or a repressive state. Consistent with in vitro studies, we found that specific TFIID subunits, in addition to cross-linking at the core promoter, made precise cross-links at Rap1 sites, which we interpret to reflect native Rap1-TFIID interactions. Our findings suggest how sequence-specific DNA binding regulates nucleosome positioning and transcription complex assembly >300 bp away and how coregulation coevolved with coding sequences."xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.268896.115"xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/author | "Pugh B.F."xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/author | "Reja R."xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/author | "Vinayachandran V."xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/pages | "1942-1954"xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/title | "Molecular mechanisms of ribosomal protein gene coregulation."xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/26385964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26385964 |
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| http://purl.uniprot.org/uniprot/#_P38129-mappedCitation-26385964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26385964 |
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| http://purl.uniprot.org/uniprot/#_P11938-mappedCitation-26385964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26385964 |