| http://purl.uniprot.org/citations/26386639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26386639 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present study was to elucidate whether the GATA-4/SF-1 signalling pathway is involved in the inhibitory effects of melatonin on testosterone production in both the TM3 Leydig cell line and in C57BL/6J mice. In-vitro experiments demonstrated that melatonin treatment significantly reduced testosterone levels in cell culture medium (P < 0.05 or P < 0.01); and decreased intracellular cyclic adenosine monophospha accumulation (P < 0.05 or P < 0.01) and mRNA/protein expression of GATA-4, SF-1 (NR5A1), StAR, P450SCC (CYP11A1) and 3β-HSD (P < 0.05 or P < 0.01). These effects were blocked by N-acetyl-2-benzyltryptamin, a melatonin receptor antagonist. Similar effects of melatonin on testosterone production (P < 0.05 or P < 0.01) and down-regulation of transcription factors GATA-4 and SF-1 (P < 0.01) were also observed in mice treated with intratesticular injections of melatonin. Overall, the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 expression."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.rbmo.2015.07.009"xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Tong J."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Qin F."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Shen O."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/author | "Zan L."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/name | "Reprod Biomed Online"xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/pages | "638-646"xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/title | "Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors."xsd:string |
| http://purl.uniprot.org/citations/26386639 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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