| http://purl.uniprot.org/citations/26388029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26388029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26388029 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein ubiquitination patterns are an important component of cellular signaling. The WD-repeat protein WDR48 (USP1-associated factor UAF-1) stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46. To understand how WDR48 exerts its effect on the USP scaffold, we determined structures of the ternary WDR48:USP46:ubiquitin complex. WDR48 interacts with the USP46 fingers subdomain via a relatively small, highly polar surface on the top center of the WDR48 β propeller. In addition, WDR48 has a novel ancillary domain and a C-terminal SUMO-like domain encircling the USP46-bound ubiquitin. Mutation of residues involved in the WDR48:USP46 interaction abrogated both binding and deubiquitinase activity of the complex. An analogous mutation in USP1 similarly blocked WDR48-dependent activation. Our data suggest a possible mechanism of deubiquitinase stimulation via stabilization and prolonged residence time of substrate. The unprecedented mode of interaction between the USP fingers domain and the WD-repeat β propeller serves as a prototypical example for this family of deubiquitinases."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2015.08.010"xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2015.08.010"xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Schoeffler A.J."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Schoeffler A.J."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Newton K."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Newton K."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Harris S.F."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Harris S.F."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Dueber E.C."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Dueber E.C."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Starovasnik M.A."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Starovasnik M.A."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Wickliffe K."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/author | "Wickliffe K."xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/pages | "2043-2054"xsd:string |
| http://purl.uniprot.org/citations/26388029 | http://purl.uniprot.org/core/pages | "2043-2054"xsd:string |