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http://purl.uniprot.org/citations/26397108http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26397108http://www.w3.org/2000/01/rdf-schema#comment"

Background/aim

Recent genome-wide association studies have identified several loci influencing lipid levels. The present study focused on the triglycerides (TG)-associated locus, the APOA4-APOA5-ZNF259-BUD13 gene cluster on chromosome 11, to explore the role of genetic variants in this gene cluster in the development of increasing TG levels and coronary heart disease (CHD).

Methodology/principal findings

Six single nucleotide polymorphisms (SNPs), rs4417316, rs651821, rs6589566, rs7396835, rs964184 and rs17119975, in the APOA4-APOA5-ZNF259-BUD13 gene cluster were selected and genotyped in 5374 healthy Chinese subjects. There were strong significant associations between the six SNPs and TG levels (P < 1.0 × 10(-8)). Moreover, a weighted genotype score was found to be associated with TG levels (P = 3.28 × 10(-13)). The frequencies of three common haplotypes were observed to be significantly different between the high TG group and the low TG group (P < 0.05). However, no significant effects were found for the SNPs regarding susceptibility to CHD in the Chinese case-control populations.

Conclusions/significance

This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0138652"xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Chen J."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Fu Q."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Tang X."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Zhou L."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Zhang M."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Jing J."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/author"Su L."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/pages"e0138652"xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/title"Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population."xsd:string
http://purl.uniprot.org/citations/26397108http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/26397108http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26397108
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