| http://purl.uniprot.org/citations/26399972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26399972 | http://www.w3.org/2000/01/rdf-schema#comment | "Periodontal ligament-associated protein 1 (PLAP-1)/asporin is an extracellular matrix protein preferentially expressed in periodontal ligaments. PLAP-1/asporin inhibits the cytodifferentiation and mineralization of periodontal ligament cells and has important roles in the maintenance of periodontal tissue homeostasis. However, the involvement of PLAP-1/asporin in inflammatory responses during periodontitis is poorly understood. This study hypothesized that PLAP-1/asporin might affect the pathogenesis of periodontitis by regulating periodontopathic bacteria-induced inflammatory responses. Proinflammatory cytokine expression induced by Toll-like receptor 2 (TLR2) and TLR4 was significantly downregulated when PLAP-1/asporin was overexpressed in periodontal ligament cells. Similarly, recombinant PLAP-1/asporin inhibited TLR2- and TLR4-induced proinflammatory cytokine expression in macrophages. We also confirmed that NF-κB activity induced by TLR2 and TLR4 signaling was suppressed by the addition of recombinant PLAP-1/asporin. Furthermore, IκB kinase α degradation induced by TLR4 was reduced by PLAP-1/asporin. Immunoprecipitation assays demonstrated the binding abilities of PLAP-1/asporin to both TLR2 and TLR4. Taken together, PLAP-1/asporin negatively regulates TLR2- and TLR4-induced inflammatory responses through direct molecular interactions. These findings indicate that PLAP-1/asporin has a defensive role in periodontitis lesions by suppressing pathophysiologic TLR signaling and that the modulating effects of PLAP-1/asporin might be useful for periodontal treatments."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.org/dc/terms/identifier | "doi:10.1177/0022034515606859"xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Yamada S."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Murakami S."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Tsushima K."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Sakashita H."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Awata T."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Yanagita M."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Kajikawa T."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Fujihara C."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/author | "Yamaba S."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/name | "J Dent Res"xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/pages | "1706-1714"xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/title | "PLAP-1/Asporin Regulates TLR2- and TLR4-induced Inflammatory Responses."xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/26399972 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26399972 |
| http://purl.uniprot.org/citations/26399972 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26399972 |
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