| http://purl.uniprot.org/citations/26400647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26400647 | http://www.w3.org/2000/01/rdf-schema#comment | "The functional assembly of the synaptic release machinery is well understood; however, how signalling factors modulate this process remains unknown. Recent studies suggest that Wnts play a role in presynaptic function. To examine the mechanisms involved, we investigated the interaction of release machinery proteins with Dishevelled-1 (Dvl1), a scaffold protein that determines the cellular locale of Wnt action. Here we show that Dvl1 directly interacts with Synaptotagmin-1 (Syt-1) and indirectly with the SNARE proteins SNAP25 and Syntaxin (Stx-1). Importantly, the interaction of Dvl1 with Syt-1, which is regulated by Wnts, modulates neurotransmitter release. Moreover, presynaptic terminals from Wnt signalling-deficient mice exhibit reduced release probability and are unable to sustain high-frequency release. Consistently, the readily releasable pool size and formation of SNARE complexes are reduced. Our studies demonstrate that Wnt signalling tunes neurotransmitter release and identify Syt-1 as a target for modulation by secreted signalling proteins."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9302"xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Boyle K."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Ciani L."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Stamatakou E."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "McLeod F."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Gibb A."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Salinas P.C."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Lopes D.M."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Marzo A."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Rosso S.B."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/author | "Anane D."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/pages | "8302"xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/title | "Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1."xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26400647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26400647 |
| http://purl.uniprot.org/citations/26400647 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26400647 |
| http://purl.uniprot.org/uniprot/P51141#attribution-8794EB73BFFF8EBA7CD677D36A867FB2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26400647 |
| http://purl.uniprot.org/uniprot/P24383#attribution-8794EB73BFFF8EBA7CD677D36A867FB2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26400647 |
| http://purl.uniprot.org/uniprot/#_A6IGE2-mappedCitation-26400647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26400647 |
| http://purl.uniprot.org/uniprot/#_P21707-mappedCitation-26400647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26400647 |
| http://purl.uniprot.org/uniprot/#_H6RXZ1-mappedCitation-26400647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26400647 |