| http://purl.uniprot.org/citations/26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26402606 | http://www.w3.org/2000/01/rdf-schema#comment | "Ultrafast neurotransmitter release requires tight colocalization of voltage-gated Ca(2+) channels with primed, release-ready synaptic vesicles at the presynaptic active zone. RIM-binding proteins (RIM-BPs) are multidomain active zone proteins that bind to RIMs and to Ca(2+) channels. In Drosophila, deletion of RIM-BPs dramatically reduces neurotransmitter release, but little is known about RIM-BP function in mammalian synapses. Here, we generated double conditional knockout mice for RIM-BP1 and RIM-BP2, and analyzed RIM-BP-deficient synapses in cultured hippocampal neurons and the calyx of Held. Surprisingly, we find that in murine synapses, RIM-BPs are not essential for neurotransmitter release as such, but are selectively required for high-fidelity coupling of action potential-induced Ca(2+) influx to Ca(2+)-stimulated synaptic vesicle exocytosis. Deletion of RIM-BPs decelerated action-potential-triggered neurotransmitter release and rendered it unreliable, thereby impairing the fidelity of synaptic transmission. Thus, RIM-BPs ensure optimal organization of the machinery for fast release in mammalian synapses without being a central component of the machinery itself."xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2015.08.027"xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/author | "Gonzalez A."xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/author | "Acuna C."xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/pages | "1234-1247"xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/title | "RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release."xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/26402606 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26402606 |
| http://purl.uniprot.org/citations/26402606 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26402606 |
| http://purl.uniprot.org/uniprot/Q7TNF8#attribution-02D9BEFBA2F63F0FCEF8B441618D4813 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26402606 |
| http://purl.uniprot.org/uniprot/Q80U40#attribution-02D9BEFBA2F63F0FCEF8B441618D4813 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26402606 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGW5-mappedCitation-26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402606 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEC0-mappedCitation-26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402606 |
| http://purl.uniprot.org/uniprot/#_D3YYY2-mappedCitation-26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402606 |
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| http://purl.uniprot.org/uniprot/#_D3YXS2-mappedCitation-26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402606 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFB0-mappedCitation-26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402606 |
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| http://purl.uniprot.org/uniprot/#_A0A5F8MPV6-mappedCitation-26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402606 |
| http://purl.uniprot.org/uniprot/#_F7CD74-mappedCitation-26402606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402606 |