| http://purl.uniprot.org/citations/26402907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26402907 | http://www.w3.org/2000/01/rdf-schema#comment | "Kaposi's sarcoma (KS) is a highly disseminated angiogenic tumor of endothelial cells linked to infection by Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV encodes more than two dozens of miRNAs but their roles in KSHV-induced tumor dissemination and metastasis remain unknown. Here, we found that ectopic expression of miR-K12-3 (miR-K3) promoted endothelial cell migration and invasion. Bioinformatics and luciferase reporter analyses showed that miR-K3 directly targeted G protein-coupled receptor (GPCR) kinase 2 (GRK2, official gene symbol ADRBK1). Importantly, overexpression of GRK2 reversed miR-K3 induction of cell migration and invasion. Furthermore, the chemokine receptor CXCR2, which was negatively regulated by GRK2, was upregulated in miR-K3-transduced endothelial cells. Knock down of CXCR2 abolished miR-K3-induced cell migration and invasion. Moreover, miR-K3 downregulation of GRK2 relieved its direct inhibitory effect on AKT. Both CXCR2 induction and the release of AKT from GRK2 were required for miR-K3 maximum activation of AKT and induction of cell migration and invasion. Finally, deletion of miR-K3 from the KSHV genome abrogated its effect on the GRK2/CXCR2/AKT pathway and KSHV-induced migration and invasion. Our data provide the first-line evidence that, by repressing GRK2, miR-K3 facilitates cell migration and invasion via activation of CXCR2/AKT signaling, which likely contribute to the dissemination of KSHV-induced tumors."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1005171"xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Gao S.J."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Renne R."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Yan Q."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Bai Z."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Qin D."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/author | "Krueger B.J."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/pages | "e1005171"xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/title | "A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling."xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/26402907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26402907 |
| http://purl.uniprot.org/citations/26402907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26402907 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z392-mappedCitation-26402907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402907 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3I6-mappedCitation-26402907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402907 |
| http://purl.uniprot.org/uniprot/#_P25098-mappedCitation-26402907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26402907 |