| http://purl.uniprot.org/citations/26408666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26408666 | http://www.w3.org/2000/01/rdf-schema#comment | "Encephalomyocarditis virus (EMCV) infection of macrophages results in the expression of a number of inflammatory and antiviral genes, including inducible NO synthase (iNOS) and cyclooxygenase (COX)-2. EMCV-induced macrophage activation has been shown to require the presence of CCR5 and the activation of PI3K-dependent signaling cascades. The purpose of this study was to determine the role of PI3K in regulating the macrophage responses to EMCV. We show that PI3K regulates EMCV-stimulated iNOS and COX-2 expression by two independent mechanisms. In response to EMCV infection, Akt is activated and regulates the translation of iNOS and COX-2 through the mammalian target of rapamycin complex (mTORC)1. The activation of mTORC1 during EMCV infection is CCR5-dependent and appears to function in a manner that promotes the translation of iNOS and COX-2. CCR5-dependent mTORC1 activation functions as an antiviral response, as mTORC1 inhibition increases the expression of EMCV polymerase. PI3K also regulates the transcriptional induction of iNOS and COX-2 in response to EMCV infection by a mechanism that is independent of Akt and mTORC1 regulation. These findings indicate that macrophage expression of the inflammatory genes iNOS and COX-2 occurs via PI3K- and Akt-dependent translational control of mTORC1 and PI3K-dependent, Akt-independent transcriptional control."xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1500704"xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/author | "Corbett J.A."xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/author | "Naatz A."xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/author | "Shaheen Z.R."xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/pages | "4406-4414"xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/title | "CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection."xsd:string |
| http://purl.uniprot.org/citations/26408666 | http://purl.uniprot.org/core/volume | "195"xsd:string |
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