DESCRIBE <http://purl.uniprot.org/citations/26408699>

Subject	Predicate	Object
http://purl.uniprot.org/citations/26408699	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26408699	http://www.w3.org/2000/01/rdf-schema#comment	" Background Long noncoding RNA ANRIL (antisense non-coding RNA in the INK4 locus) represses p15 and p16, which induce cell-cycle arrest at G1 phase, leading to enhanced cell proliferation of normal fibroblasts. Herein we report that ANRIL is also involved in the regulation of cancer-cell proliferation. Materials and methods HeLa and H1299 cells were transfected with ANRIL siRNAs. At 72 h post-transfection, cells were subjected to quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and cell-cycle analysis. Results qRT-PCR showed that ANRIL is highly expressed in these cancer cells compared to normal fibroblasts. Depletion of ANRIL increased p15 expression, with no impact on p16 or ARF (alternative reading frame) expression, and caused cell-cycle arrest at the G2/M phase, leading to inhibition of proliferation of H1299 and HeLa cells. Conclusion ANRIL positively regulates the proliferation of cancer cells, such as H1299 and HeLa cells, via regulating p15 and other genes related to G2/M phase control."xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/author	"Inoue Y."xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/author	"Okamoto H."xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/author	"Kotake Y."xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/author	"Murasaki C."xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/author	"Naemura M."xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/date	"2015"xsd:gYear
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/name	"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/pages	"5377-5382"xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/title	"Long Noncoding RNA ANRIL Regulates Proliferation of Non-small Cell Lung Cancer and Cervical Cancer Cells."xsd:string
http://purl.uniprot.org/citations/26408699	http://purl.uniprot.org/core/volume	"35"xsd:string
http://purl.uniprot.org/citations/26408699	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/26408699
http://purl.uniprot.org/citations/26408699	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/26408699
http://purl.uniprot.org/uniprot/#_P42772-mappedCitation-26408699	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/#_K7PPU3-mappedCitation-26408699	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/#_Q9UM95-mappedCitation-26408699	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/#_Q5ZEY8-mappedCitation-26408699	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/#_Q86WJ4-mappedCitation-26408699	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/#_Q8NIA6-mappedCitation-26408699	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/Q86WJ4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/K7PPU3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/P42772	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/Q5ZEY8	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26408699
http://purl.uniprot.org/uniprot/Q8NIA6	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26408699